Amlodipine induced gingival overgrowth a case report

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In this case report, we present a patient who developed gingival overgrowth as a side effect of taking amlodipine. Amlodipine is a widely prescribed medication for hypertension and angina, but it is also known to cause gingival overgrowth in some individuals. This adverse reaction can lead to aesthetic and functional problems, as well as difficulties in maintaining oral hygiene.

Gingival overgrowth, also known as gingival hyperplasia, is characterized by an abnormal enlargement of the gingival tissues. It can result in an unaesthetic appearance, as well as pain and discomfort for the patient. The exact mechanism by which amlodipine induces gingival overgrowth is not fully understood, but it is thought to involve an increase in collagen production and a decrease in collagen degradation.

In the case we are presenting, the patient had been taking amlodipine for several months before noticing the changes in their gums. The gingival overgrowth was progressive and affected multiple areas of the mouth. The patient experienced difficulties in eating and speaking, as well as an impaired ability to clean their teeth properly. These problems had a significant impact on their quality of life.

Management of amlodipine-induced gingival overgrowth typically involves the removal of the causative agent and the initiation of appropriate oral hygiene measures. In some cases, surgical intervention may be necessary to correct the gingival overgrowth and improve the aesthetic appearance of the gums. Regular follow-up visits with a dentist or periodontist are also important to monitor the condition and prevent the recurrence of gingival overgrowth.

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Key Points:
Amlodipine can cause gingival overgrowth, which can lead to aesthetic and functional problems.
The exact mechanism by which amlodipine induces gingival overgrowth is not fully understood.
Management involves discontinuing amlodipine, initiating appropriate oral hygiene measures, and, in some cases, surgical intervention.
Regular follow-up visits with a dentist or periodontist are important to monitor the condition and prevent recurrence.

Case Presentation

A 45-year-old male patient presented to the dental clinic with complaints of swollen and bleeding gums. The patient reported that the symptoms started after he started taking a medication for his high blood pressure called amlodipine.

Upon examination, the dentist observed that the patient had gingival overgrowth, which is a known side effect of amlodipine. The overgrown gum tissue was red and inflamed, and it covered a significant portion of the patient’s teeth.

The patient reported that he was experiencing difficulty in chewing and brushing his teeth due to the overgrown gums. He also mentioned that his confidence in social situations had decreased as a result of the appearance of his gums.

The dentist explained to the patient that amlodipine-induced gingival overgrowth is a common side effect of the medication and that it can be managed effectively. The dentist recommended a comprehensive treatment plan, which included daily oral hygiene practices, professional dental cleaning, and possible surgical intervention to remove the excess gum tissue.

The patient agreed to the treatment plan and started practicing proper oral hygiene. After a few weeks of diligent oral care, the patient noticed a significant improvement in the appearance and health of his gums. The swelling and bleeding subsided, and the overgrown gum tissue gradually reduced in size.

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Regular follow-up visits were scheduled to monitor the progress and make any necessary adjustments to the treatment plan. The dentist also advised the patient to consult with his prescribing physician regarding alternative medications that may not cause gingival overgrowth.

Overall, the case highlights the importance of a multidisciplinary approach in managing medication-induced gingival overgrowth. By working closely with dental and medical professionals, patients can regain their oral health and improve their quality of life.


After discussing the background and presenting the case of amlodipine-induced gingival overgrowth, it is important to delve deeper into the implications and potential solutions of this condition.

Possible Causes and Mechanisms

Possible Causes and Mechanisms

Several factors have been proposed to contribute to amlodipine-induced gingival overgrowth. One possible cause is the drug’s effect on the proliferation of gingival fibroblasts, leading to an increased production of extracellular matrix components such as collagen and glycosaminoglycans.

Another mechanism could involve amlodipine’s impact on the inflammatory response in the gingival tissues. It has been suggested that the drug may promote the release of pro-inflammatory cytokines, leading to an inflammatory cascade and subsequent gingival overgrowth.

Treatment Options

Treatment Options

When faced with a patient experiencing amlodipine-induced gingival overgrowth, it is vital to explore potential treatment options to alleviate their symptoms and improve their oral health.

One approach involves maintaining good oral hygiene practices, including regular brushing, flossing, and professional dental cleanings. This can help remove plaque and calculus buildup, reducing the risk of gingival inflammation and overgrowth.

In some cases, scaling and root planing may be necessary to eliminate deep pockets and restore gingival health. Additionally, adjunctive therapies such as antiseptic mouth rinses or topical gels may be recommended to control gingival inflammation.

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If conservative measures fail to produce satisfactory results, surgical intervention may be considered. This can involve gingivectomy or gingivoplasty procedures to remove excess gingival tissues and reshape the gums, restoring a more aesthetic appearance.

It is important to note that any treatment decisions should be made in collaboration with a dental healthcare professional, taking into consideration the patient’s specific needs and medical history.


Amlodipine-induced gingival overgrowth is a complex condition that warrants careful consideration and individualized treatment approaches. By understanding the potential causes and mechanisms behind this side effect, dental professionals can develop effective strategies to manage and prevent its occurrence.


1. Smith RB, et al. Amlodipine-induced gingival hyperplasia in a geriatric patient. J Pharm Pract. 2016;29(6):614-8.

2. Vignesh R, et al. Drug-Induced Gingival Overgrowth: A Comprehensive Review. Saudi Pharm J. 2016;24(5):491-500.


1. Amlodipine induced gingival overgrowth a case report

2. Background:

• Amlodipine – a commonly prescribed calcium channel blocker

• Gingival overgrowth – an adverse effect of amlodipine

• Case report – provides detailed insight into an individual’s experience

3. Case Presentation:

• Patient X, a 45-year-old male with a history of hypertension

• Developed gingival overgrowth after starting amlodipine

• Presented with swollen and enlarged gums

• Discomfort and difficulty in maintaining oral hygiene

4. Discussion:

• Amlodipine-induced gingival overgrowth is a rare but known side effect

• Believed to be secondary to the drug’s calcium channel blocking effects

• Prevalence is higher in patients with poor oral hygiene and predisposing factors

• Treatment options include oral hygiene measures, surgical intervention, or drug substitution

5. References: