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What is Amlodipine?

What is Amlodipine?

Amlodipine is a prescription medication that belongs to a class of drugs called calcium channel blockers. It is used to treat high blood pressure (hypertension) and certain types of chest pain (angina).

Calcium channel blockers work by relaxing the blood vessels, allowing blood to flow more easily. Amlodipine specifically affects the muscles in the walls of the arteries, causing them to relax and dilate. This reduces the workload on the heart and improves blood flow.

How Does Amlodipine Work?

Amlodipine works by blocking the entry of calcium into the smooth muscle cells of the blood vessels and heart. Calcium is needed for muscle contraction, so by blocking its entry, amlodipine causes the blood vessels to relax and widen. This allows blood to flow more freely, reducing blood pressure and relieving chest pain.

Amlodipine is typically taken once a day, with or without food. It is important to take the medication as directed by your doctor. Do not stop taking amlodipine without first consulting your doctor, as suddenly stopping may worsen your condition.

Common side effects of amlodipine include headache, dizziness, fatigue, and swelling of the ankles or feet. Serious side effects may include low blood pressure, fainting, and fast or irregular heartbeat. It is important to discuss any concerns or questions with your doctor.

Why is Amlodipine prescribed?

Amlodipine is a medication that belongs to a class of drugs called calcium channel blockers. It is mainly prescribed for the treatment of high blood pressure (hypertension) and chest pain caused by angina. It helps relax the blood vessels, allowing blood to flow more easily and reducing the workload on the heart. By lowering blood pressure, Amlodipine helps to prevent strokes, heart attacks, and kidney problems. It may be prescribed alone or in combination with other medications to achieve better blood pressure control.

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Side Effects

When taking Amlodipine, it is important to be aware of the potential side effects that may occur. While not everyone experiences side effects, it is still important to be informed about them.

Common side effects:

  • Fatigue
  • Swelling in the ankles or feet
  • Flushing
  • Headache
  • Dizziness

These common side effects are usually mild and may disappear on their own as your body adjusts to the medication. If any of these side effects persist or worsen, it is important to consult your doctor.

Serious side effects:

  • Shortness of breath
  • Chest pain
  • Rapid or irregular heartbeat
  • Severe dizziness or fainting
  • Yellowing of the skin or eyes

While less common, these serious side effects may require immediate medical attention. If you experience any of these symptoms, seek medical help right away.

It is important to remember that this is not a complete list of side effects. If you have any concerns or questions about side effects while taking Amlodipine, it is best to consult with your healthcare provider.

Common side effects

When taking Amlodipine, there are some common side effects that may occur. It is important to be aware of these side effects and to consult your doctor if they persist or become bothersome.

Some common side effects of Amlodipine include:

  • Headache: This is a common side effect that may occur when taking Amlodipine. If you experience a persistent or severe headache, it is recommended to consult your doctor.
  • Dizziness: Dizziness may occur when taking Amlodipine, especially when getting up from a sitting or lying position. It is important to be cautious and avoid activities that require alertness until you know how Amlodipine affects you.
  • Fatigue: Feeling tired or exhausted is a common side effect of Amlodipine. If you experience extreme fatigue or if it affects your daily activities, it is advised to consult your doctor.
  • Nausea: Some individuals may experience nausea or an upset stomach when taking Amlodipine. If this side effect persists or becomes severe, it is recommended to seek medical advice.
  • Swelling of the ankles or feet: Amlodipine may cause fluid retention, resulting in swelling of the ankles or feet. If you notice significant swelling or if it becomes painful, it is important to inform your doctor.

These are just a few of the common side effects that may occur when taking Amlodipine. It is important to remember that everyone may react differently to medications, and these side effects may vary in severity.

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If you experience any new or worsening symptoms while taking Amlodipine, it is crucial to consult your healthcare provider for further evaluation and guidance.

Serious side effects

While Amlodipine is generally well-tolerated, there are some serious side effects that may occur in rare cases. It is important to be aware of these potential risks and to seek medical attention if they occur.

Side Effect Description
Severe hypotension A significant drop in blood pressure that can cause dizziness, fainting, or lightheadedness. This can be especially dangerous for individuals with underlying heart conditions.
Heart palpitations An irregular or rapid heartbeat that may cause discomfort or a feeling of skipped beats. This can be a sign of a more serious heart condition.
Chest pain Severe chest pain or discomfort that may radiate to the arms, back, neck, or jaw. This could be a symptom of a heart attack and requires immediate medical attention.
Swelling of the ankles or feet Unusual or excessive swelling in the lower extremities, which may be a sign of fluid retention or heart failure.
Jaundice A yellowing of the skin or eyes, which can indicate liver problems. This should be reported to a healthcare provider immediately.
Allergic reaction An allergic reaction to Amlodipine can cause hives, itching, rash, difficulty breathing, or swelling of the face, lips, tongue, or throat. This is a medical emergency and requires immediate attention.

These serious side effects are rare, but it is important to be aware of them and to contact a healthcare provider if they occur while taking Amlodipine.


Before taking Amlodipine, it is important to be aware of certain precautions to ensure your safety and well-being:

1. Medical Conditions

If you have any pre-existing medical conditions, especially liver disease or heart-related problems, it is crucial to inform your doctor. Amlodipine may not be suitable or require dose adjustments in such cases.

2. Pregnancy and Breastfeeding

If you are pregnant or planning to become pregnant, it is important to discuss the potential risks and benefits of using Amlodipine with your doctor. Amlodipine may be harmful to the unborn baby, and alternative treatments may be considered. Similarly, if you are breastfeeding, it is important to notify your doctor as Amlodipine may pass into breast milk and may harm the nursing infant.

Note: Do not stop taking Amlodipine without consulting your doctor first, as suddenly stopping the medication may lead to a sudden increase in blood pressure, which can have adverse effects on your health.

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3. Allergies and Sensitivities

3. Allergies and Sensitivities

If you have a known allergy to Amlodipine or any other calcium channel blockers, it is important to inform your doctor beforehand. Additionally, discuss any history of allergic reactions to medications, food items, dyes, or preservatives.

Note: If you experience any signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek medical attention immediately.

4. Drug Interactions

Amlodipine may interact with certain medications, such as other blood pressure-lowering drugs, antifungal medications, antibiotics, and HIV protease inhibitors. It is essential to inform your doctor about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements.

Note: Avoid starting any new medication while taking Amlodipine, unless advised by your doctor.

By following these precautions and discussing any concerns with your healthcare provider, you can ensure the safe and effective use of Amlodipine.

Interactions with other drugs

Amlodipine may interact with other drugs, which can affect how it works or increase the risk of side effects. It is important to inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements.

Some drugs that may interact with amlodipine include:

Drug Interaction
Simvastatin Co-administration of simvastatin and amlodipine may increase the risk of muscle pain, weakness, and rhabdomyolysis (a serious condition characterized by the breakdown of muscle fibers).
Warfarin Amlodipine may increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding. Close monitoring of blood clotting times is recommended.
Cyclosporine Concomitant use of amlodipine and cyclosporine may increase the blood levels of cyclosporine, which can lead to toxic effects on the kidneys. Regular kidney function tests are necessary.
Grapefruit juice Consuming grapefruit juice while taking amlodipine may increase the blood levels of amlodipine, leading to an increased risk of side effects. It is best to avoid grapefruit juice or consult your doctor.

These are not the only drugs that may interact with amlodipine. Always consult your healthcare provider before starting or stopping any medications while taking amlodipine.

Allergic reactions

Allergic reactions to Amlodipine are rare, but they can occur. If you experience any of the following symptoms, stop taking Amlodipine and seek medical attention immediately:

  • Rash or hives
  • Swelling of the face, lips, tongue, or throat
  • Difficulty breathing or swallowing
  • Chest tightness

These symptoms may indicate a severe allergic reaction, which can be life-threatening if not treated promptly. If you have a known allergy to Amlodipine or any other medications, inform your doctor before starting this medication.

It’s also important to note that some people may develop an allergic reaction to Amlodipine after taking it for an extended period of time. If you notice any new symptoms or skin changes while taking this medication, consult your doctor immediately.